منابع مشابه
Adventitial Fibroblast Heterogeneity
vascular function and structure from the “outside-in.” The purpose of this review is to provide evidence that, in response to injury, resident adventitial fibroblasts can be activated to exhibit different functional characteristics that contribute significantly to pulmonary vascular remodeling. Data will be presented supporting the concept that fibroblasts (in some cases only specific subpopula...
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Dermal fibroblasts are a dynamic and diverse population of cells whose functions in skin in many respects remain unknown. Normal adult human skin contains at least three distinct subpopulations of fibroblasts, which occupy unique niches in the dermis. Fibroblasts from each of these niches exhibit distinctive differences when cultured separately. Specific differences in fibroblast physiology are...
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Fibroblast heterogeneity applies to both phenotypic and functional properties exhibited by a fibroblast population within or across tissues (Mc Culloch et al) There is significant evidence that fibroblasts are heterogeneous with respect to functional properties, and that certain subpopulations of these cells may be clonally selected and expanded in diseased tissues. There are wide variations of...
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Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibit...
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Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins and profound tissue remodeling. Myofibroblasts have been shown to arise from interstitial fibroblasts, epithelial to mesenchymal transition of type II alveolar epithelial cells, an...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2001
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)61768-3